Article
Klotho Lacks an FGF23-Independent Role in Mineral Homeostasis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2017
Andrukhova Olena, Bayer Jessica, Schüler Christiane, Zeitz Ute, Murali Sathish K, Ada Sibel, Alvarez-Pez Jose M, Smorodchenko Alina, Erben Reinhold G
Abstract excerpt
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating vitamin D hormone production and renal handling of minerals by signaling through an FGF receptor/αKlotho (Klotho) receptor complex. Whether Klotho has FGF23-independent effects on mineral homeostasis is a controversial issue. Here, we aimed to shed more light on this controversy by comparing male and female triple knockout mice with...
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