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Article

Renal calcification in mice homozygous for the disrupted type IIa Na/Pi cotransporter gene Npt2.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2003

Chau Hien, El-Maadawy Sherif, McKee Marc D, Tenenhouse Harriet S

Abstract excerpt

Mice homozygous for the disrupted renal type IIa sodium/phosphate (Na/Pi) cotransporter gene (Npt2-/-) exhibit renal Pi wasting, hypophosphatemia, and an adaptive increase in the serum concentration of 1,25-dihydroxyvitamin D with associated hypercalcemia and hypercalciuria. Because hypercalciuria is a risk factor for nephrocalcinosis, we determined whether Npt2-/- mice form renal stones. Analysis of renal...

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Identifiers

PMID: 12674325
DOI: 10.1359/jbmr.2003.18.4.644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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