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Article

Central role of the proximal tubular αKlotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism.

Scientific reports - 2 May 2018

Takeshita Ai, Kawakami Kazuki, Furushima Kenryo, Miyajima Masayasu, Sakaguchi Kazushige

Abstract excerpt

Fibroblast growth factor 23 (FGF23) plays critical roles in phosphate handling and vitamin D metabolism in the kidney. However, the effector cells of FGF23 in the kidney remain unclear. αKlotho, a putative enzyme possessing β-glucuronidase activity and also a permissive co-receptor for FGF23 to bind to FGF receptors (FGFRs), is expressed most abundantly in distal convoluted tubules, whereas it is expressed...

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Identifiers

PMID: 29720668
DOI: 10.1038/s41598-018-25087-3
PMCID: PMC5932018

Genes

FGF23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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