Article
Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression.
American journal of physiology. Renal physiology - 1 May 2021
Ostrosky-Frid Mauricio, Chávez-Canales María, Zhang Jinwei, Andrukhova Olena, Argaiz Eduardo R, Lerdo-de-Tejada Fernando, Murillo-de-Ozores Adrian, Sanchez-Navarro Andrea, Rojas-Vega Lorena, Bobadilla Norma A, Vazquez Norma, Castañeda-Bueno María, Alessi Dario R, Gamba Gerardo
Abstract excerpt
The physiological role of the shorter isoform of with no lysine kinase (WNK)1 that is exclusively expressed in the kidney (KS-WNK1), with particular abundance in the distal convoluted tubule, remains elusive. KS-WNK1, despite lacking the kinase domain, is nevertheless capable of stimulating the NaCl cotransporter, apparently through activation of WNK4. It has recently been shown that a less severe form of...
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