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Article

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2009

Nakatani Teruyo, Sarraj Bara, Ohnishi Mutsuko, Densmore Michael J, Taguchi Takashi, Goetz Regina, Mohammadi Moosa, Lanske Beate, Razzaque M Shawkat

Abstract excerpt

A major breakthrough in systemic phosphate homeostasis regulation was achieved by the demonstration of strikingly similar physical, morphological, and biochemical phenotypes of fibroblast growth factor 23 (Fgf23) and klotho ablated mice, which led to identification of klotho as an Fgf23 signaling cofactor. Here, we generated Fgf23 and klotho double-knockout (Fgf23(-/-)/klotho(-/-)) mice to test the hypothesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18835926
DOI: 10.1096/fj.08-114397
PMCID: PMC2630784

Genes

FGF23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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