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Article

Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection.

Nature genetics - 1 Oct 2017

Gazal Steven, Finucane Hilary K, Furlotte Nicholas A, Loh Po-Ru, Palamara Pier Francesco, Liu Xuanyao, Schoech Armin, Bulik-Sullivan Brendan, Neale Benjamin M, Gusev Alexander, Price Alkes L

Abstract excerpt

Recent work has hinted at the linkage disequilibrium (LD)-dependent architecture of human complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability. Here we analyzed summary statistics from 56 complex traits (average N = 101,401) by extending stratified LD score regression to continuous annotations. We determined that SNPs with low LLD have significantly larger per-SNP heritability...

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PMID: 28892061
DOI: 10.1038/ng.3954
PMCID: PMC6133304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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