Article

Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

2016-10-19

Abstract excerpt

Recent work has hinted at the linkage disequilibrium (LD) dependent architecture of human complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability after conditioning on their minor allele frequency (MAF). However, this has not been formally assessed, quantified or biologically interpreted. Here, we analyzed summary statistics from 56 complex diseases and traits (average N = 101,401)...

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Literature Corpus work: 9257249c-356a-529a-8e25-8a110e3602be
DOI: 10.1101/082024

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