Article

Nuclear morphology predicts cell survival to cisplatin chemotherapy

2022-09-19

Abstract excerpt

In this study, we characterized nuclear morphology and function as cancer cells underwent recovery following chemotherapeutic treatment to identify the unique characteristics associated with treatment resistance and successful survival. Cells that survived following treatment and resisted therapy-induced cell death were predominantly mononucleated with increased nuclear/cellular size, enabled by continuous endocyc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 029f0a65-4877-5404-b17c-888fbd09ab47
DOI: 10.1101/2022.09.19.508515

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nuclear morphology predicts cell survival to cisplatin chemotherapyDOI 10.1101/2022.09.19.508515Read

PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer CellsSemantic proximity Read

Polyploidy in Cancer: Causal Mechanisms, Cancer-Specific Consequences, and Emerging TreatmentsSemantic proximity Read

Macroautophagy-aided elimination of chromatinSemantic proximity Read

Molecular mechanisms of tumor resistance to radiotherapySemantic proximity Read

Amitotic Cell Division, Malignancy, and Resistance to Anticancer Agents: A Tribute to Drs. Walen and RajaramanSemantic proximity Read

Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cellsSemantic proximity Read

Anastasis: cell recovery mechanisms and potential role in cancerSemantic proximity Read

Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid CellsSemantic proximity Read

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damageSemantic proximity Read

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotypeSemantic proximity Read

Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.Semantic proximity Read

Activation of Meiosis-Specific Genes Is Associated with Depolyploidization of Human Tumor Cells following Radiation-Induced Mitotic CatastropheSemantic proximity Read