Article

Defects in the DNA Damage Response of Patient-derived Endometriosis Stromal Cells

2025-10-30

Abstract excerpt

With each menstrual cycle, endometrial cells rapidly proliferate and decidualize in preparation for pregnancy. Such rapid proliferation generates replication stress and results in DNA damage with irreparable cells undergoing senescence. Here, we examine the DNA damage response (DDR) of patient-derived stromal cell lines from menstrual effluent (MenSC) of healthy donors and donors with endometriosis. We found that...

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Literature Corpus work: ccf78e30-9e2d-5128-8a29-3a962bd0446b
DOI: 10.1101/2025.10.29.685406

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