Article
Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome.
Nature communications - 13 Apr 2018
Bonora G, Deng X, Fang H, Ramani V, Qiu R, Berletch J B, Filippova G N, Duan Z, Shendure J, Noble W S, Disteche C M
Abstract excerpt
The mammalian inactive X chromosome (Xi) condenses into a bipartite structure with two superdomains of frequent long-range contacts, separated by a hinge region. Using Hi-C in edited mouse cells with allelic deletions or inversions within the hinge, here we show that the conserved Dxz4 locus is necessary to maintain this bipartite structure. Dxz4 orientation controls the distribution of contacts on the Xi, as...
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