Article

The embryonic DNA methylation program modulates the <i>cis-</i> regulatory landscape via CTCF antagonism

2023-11-16

Abstract excerpt

During mammalian embryogenesis, both the 5-cytosine DNA methylation (5meC) landscape and three-dimensional (3D) chromatin architecture are profoundly remodeled during a process known as “epigenetic reprogramming.” An understudied aspect of epigenetic reprogramming is how the 5meC flux, per se , affects the 3D genome. This is pertinent given the 5meC-sensitivity of DNA binding for a key regulator of chromosome fol...

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Literature Corpus work: 0d748f0f-1487-5d2d-8081-5e482eb26bc7
DOI: 10.1101/2023.11.16.567349

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