Article
Allelic reprogramming of 3D chromatin architecture during early mammalian development.
Nature - 12 Jul 2017
Du Zhenhai, Zheng Hui, Huang Bo, Ma Rui, Wu Jingyi, Zhang Xianglin, He Jing, Xiang Yunlong, Wang Qiujun, Li Yuanyuan, Ma Jing, Zhang Xu, Zhang Ke, Wang Yang, Zhang Michael Q, Gao Juntao, Dixon Jesse R, Wang Xiaowo, Zeng Jianyang, Xie Wei
Abstract excerpt
In mammals, chromatin organization undergoes drastic reprogramming after fertilization. However, the three-dimensional structure of chromatin and its reprogramming in preimplantation development remain poorly understood. Here, by developing a low-input Hi-C (genome-wide chromosome conformation capture) approach, we examined the reprogramming of chromatin organization during early development in mice. We found...
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