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CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation

3 Mar 2025

Abstract excerpt

BACKGROUND: Genes that escape X-chromosome inactivation (XCI) in female somatic cells vary in number and levels of escape among mammalian species and tissues, potentially contributing to species- and tissue-specific sex differences. CTCF, a master chromatin conformation regulator, is enriched at escape regions and may play an important role in regulating escape, but the molecular mechanisms remain elusive....

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Share to Developmental Biology and Gene Regulation
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sperm and Testicular Function

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PMID: 40025499
DOI: 10.1186/s12915-025-02137-7

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