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Multiscale chromatin modeling of chromosome X structural changes upon inactivation highlights the differential regulatory mechanism of <i>Xist</i>

2026-01-20

Abstract excerpt

The fundamental process of X-chromosome inactivation (XCI) involves silencing one X chromo-some in female mammals by the Xist gene within the X-inactivation center ( Xic ). While experiments have identified key regulatory elements controlling Xist expression, mechanistic details are unknown. By combining nucleosome-resolution and coarse-grained polymer modeling, we reveal multiscale Xic reorganization during X...

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Literature Corpus work
36347839-289e-5a5a-b535-ab8a8ab2da64
DOI
10.64898/2026.01.20.700676
Open publication

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Multiscale chromatin modeling of chromosome X structural changes upon inactivation highlights the differential regulatory mechanism of <i>Xist</i>DOI 10.64898/2026.01.20.700676
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