Back to search

Article

Single-cell analysis of antiviral neuroinflammatory responses in the mouse dorsal raphe nucleus

2019-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Neuroinflammatory processes have been implicated in neurodegenerative and psychiatric diseases, and limit the utility of viruses for gene delivery. Here we analyzed 60,212 single-cell RNA profiles to assess both global and cell type-specific transcriptional responses in the mouse dorsal raphe nucleus following axonal infection of neurons by rabies viruses. We identified several leukocyte populat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f5c42358-43dc-5d54-8c69-56c4f2c1ed58
DOI
10.1101/780205
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single-cell analysis of antiviral neuroinflammatory responses in the mouse dorsal raphe nucleusDOI 10.1101/780205
Single-cell and spatiotemporal transcriptomic profiling of brain immune infiltration following Venezuelan equine encephalitis virus infectionSemantic proximity
Transcriptional Response to Tick-Borne Flavivirus Infection in Neurons, Astrocytes and Microglia In Vivo and In VitroSemantic proximity
Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus 1 CNS infectionSemantic proximity
High-resolution spatial transcriptomics maps viral tropism and reveals spatially organized immune modules in viral encephalitisSemantic proximity
Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulationSemantic proximity
Intranasal HSV-1 Infection Drives Region-Specific Interferon-Dominant Microglial RemodelingSemantic proximity
Clonal CD8 T Cells Accumulate in the Leptomeninges and Communicate with Microglia in Human NeurodegenerationSemantic proximity
Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulationSemantic proximity
Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brainSemantic proximity
Phenotypic and transcriptional changes in peripheral blood mononuclear cells during alphavirus encephalitis in mice.Semantic proximity
Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infectionSemantic proximity
Spatially Resolved Microglial State Transitions Govern Strain-Specific Zika NeuropathogenesisSemantic proximity
Select a neighboring publication to make it the new centre.