Article

Nurr1 modulation mediates neuroprotective effects of statins

2021-09-16

Abstract excerpt

The ligand-sensing transcription factor Nurr1 emerges as a promising therapeutic target for neurodegenerative pathologies but Nurr1 ligands for functional studies and therapeutic validation are lacking. Here we report pronounced Nurr1 modulation by statins for which clinically relevant neuroprotective effects have been demonstrated. Several statins directly affected Nurr1 activity in cellular and cell-free setting...

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Identifiers and source

Literature Corpus work: 49902a3a-8412-55ab-8fb0-134d82214497
DOI: 10.1101/2021.09.15.460433

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