Article

Central inhibition of P2Y <sub>12</sub> R differentially regulates survival and neuronal loss in MPTP-induced Parkinsonism in mice

2021-02-03

Abstract excerpt

Parkinson’s disease (PD) is a chronic, progressive neurodegenerative condition; characterized with the degeneration of the nigrostriatal dopaminergic pathway and neuroinflammation. During PD progression, microglia, the resident immune cells in the central nervous system (CNS) display altered activity, but their role in maintaining PD development has remained unclear to date. The purinergic P2Y12 receptor (P2Y12R),...

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Literature Corpus work: af0c7319-5303-5998-9fb3-1017b9267785
DOI: 10.1101/2021.02.03.256941

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