Back to search

Article

Peripheral MC1R activation modulates immune responses and is neuroprotective in a mouse model of Parkinson's disease

2023-06-12

Abstract excerpt

<h4>Background: </h4> Melanocortin 1 receptor ( MC1R ) is a key pigmentation gene, and loss-of-function of MC1R variants that produce red hair may be associated with Parkinson’s disease (PD). We previously reported compromised dopaminergic neuron survival in Mc1r mutant mice and dopaminergic neuroprotective effects of local injection of a MC1R agonist to the brain or a systemically administered MC1R agonist with a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
accec5dc-0ab9-5dae-a88d-1556e6c0eea2
DOI
10.21203/rs.3.rs-3042571/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Peripheral MC1R activation modulates immune responses and is neuroprotective in a mouse model of Parkinson's diseaseDOI 10.21203/rs.3.rs-3042571/v1
Melanocortin 1 Receptor Activation Protects Against Alpha-Synuclein Pathologies in Models of Parkinson’s DiseaseSemantic proximity
Infiltrating Peripheral Monocyte TREM-1 Mediates Dopaminergic Neuron Injury in Substantia Nigra of Parkinson's Disease Model MiceSemantic proximity
CD200R1 loss in CNS-associated macrophages triggers T cell-driven neurodegeneration in Parkinson’s diseaseSemantic proximity
Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s diseaseSemantic proximity
Activation of central cannabinoid type 2 receptors, but not on peripheral immune cells, is required for endocannabinoid-mediated neuroprotection in Parkinson´s diseaseSemantic proximity
Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s diseaseSemantic proximity
LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal DegenerationSemantic proximity
Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s diseaseSemantic proximity
Teriflunomide attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations.Semantic proximity
Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathySemantic proximity
LRRK2-G2019S Synergizes With Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation That Precede Nigrostriatal DegenerationSemantic proximity
The role of innate and adaptive immunity in Parkinson's disease.Semantic proximity
Select a neighboring publication to make it the new centre.