Article
Transcriptome Analysis Reveals Altered Inflammatory Pathway in an Inducible Glial Cell Model of Myotonic Dystrophy Type 1.
Biomolecules - 26 Jan 2021
Azotla-Vilchis Cuauhtli N, Sanchez-Celis Daniel, Agonizantes-Juárez Luis E, Suárez-Sánchez Rocío, Hernández-Hernández J Manuel, Peña Jorge, Vázquez-Santillán Karla, Leyva-García Norberto, Ortega Arturo, Maldonado Vilma, Rangel Claudia, Magaña Jonathan J, Cisneros Bulmaro, Hernández-Hernández Oscar
Abstract excerpt
Myotonic dystrophy type 1 (DM1), the most frequent inherited muscular dystrophy in adults, is caused by the CTG repeat expansion in the 3'UTR of the DMPK gene. Mutant DMPK RNA accumulates in nuclear foci altering diverse cellular functions including alternative splicing regulation. DM1 is a multisystemic condition, with debilitating central nervous system alterations. Although a defective neuroglia communication...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.