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Article

A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Feb 2004

Tsutsui Shigeki, Schnermann Jurgen, Noorbakhsh Farshid, Henry Scot, Yong V Wee, Winston Brent W, Warren Kenneth, Power Christopher

Abstract excerpt

The neuromodulator adenosine regulates immune activation and neuronal survival through specific G-protein-coupled receptors expressed on macrophages and neurons, including the A1 adenosine receptor (A1AR). Here we show that A1AR null (A1AR-/-) mice developed a severe progressive-relapsing form of experimental allergic encephalomyelitis (EAE) compared with their wild-type (A1AR+/+) littermates. Worsened...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14960625
DOI: 10.1523/JNEUROSCI.4271-03.2004
PMCID: PMC6730323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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