Article
Identification of Serine 119 as an Effective Inhibitor Binding Site of M. tuberculosis Ubiquitin-like Protein Ligase PafA Using Purified Proteins and M. smegmatis.
EBioMedicine - 1 Apr 2018
Jiang He-Wei, Czajkowsky Daniel M, Wang Tao, Wang Xu-De, Wang Jia-Bin, Zhang Hai-Nan, Liu Cheng-Xi, Wu Fan-Lin, He Xiang, Xu Zhao-Wei, Chen Hong, Guo Shu-Juan, Li Yang, Bi Li-Jun, Deng Jiao-Yu, Xie Jin, Pei Jian-Feng, Zhang Xian-En, Tao Sheng-Ce
Abstract excerpt
Owing to the spread of multidrug resistance (MDR) and extensive drug resistance (XDR), there is a pressing need to identify potential targets for the development of more-effective anti-M. tuberculosis (Mtb) drugs. PafA, as the sole Prokaryotic Ubiquitin-like Protein ligase in the Pup-proteasome System (PPS) of Mtb, is an attractive drug target. Here, we show that the activity of purified Mtb PafA is significantly...
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