Article

Chemically-induced targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

2023-02-14

Abstract excerpt

Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving selectively directing disease-causing proteins for degradation through proteolytic systems. Our ability to exploit this targeted protein degradation (TPD) approach for antibiotic development remains nascent due to our limited understanding of which bacterial proteins will be labile TPD targets. Here, we use a genetic system to...

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Literature Corpus work: a9aede77-0652-5f9e-9e7d-30bb2a60e262
DOI: 10.1101/2023.02.14.528552

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