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Article

Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates.

The Journal of biological chemistry - 5 Dec 2008

Lin Gang, Tsu Christopher, Dick Lawrence, Zhou Xi K, Nathan Carl

Abstract excerpt

The proteasome of Mycobacterium tuberculosis (Mtb) is a validated and drug-treatable target for therapeutics. To lay ground-work for developing peptide-based inhibitors with a useful degree of selectivity for the Mtb proteasome over those of the host, we used a library of 5,920 N-acetyl tripeptid...

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Identifiers

PMID: 18829465
DOI: 10.1074/jbc.M805324200
PMCID: PMC2590702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18829465-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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