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Deep mutational scanning of EccD <sub>3</sub> reveals the molecular basis of its essentiality in the mycobacterium ESX secretion system

2024-08-24

Abstract excerpt

Tuberculosis remains the deadliest infectious disease in the world and requires novel therapeutic targets. The ESX-3 secretion system, which is essential for iron and zinc homeostasis and thus M. tuberculosis survival, is a promising target. In this study, we perform a deep mutational scan on the ESX-3 core protein EccD 3 in the model organism M. smegmatis . We systematically investigated the functional roles o...

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Literature Corpus work
eb3a10f1-2c67-5844-8300-79be0b94520d
DOI
10.1101/2024.08.23.609456
Open publication

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Deep mutational scanning of EccD <sub>3</sub> reveals the molecular basis of its essentiality in the mycobacterium ESX secretion systemDOI 10.1101/2024.08.23.609456
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