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Clinically present mycobacterium tuberculosis RNA polymerase subunit RpoB K446 mutation confers broad-spectrum antibiotics resistance via pupylation.

Bioorganic chemistry - 1 Feb 2026

Shen Qinglei, Huang Yu, Huo Fengmin, Xu Hongxiang, Li Man, Huang Lingxi, Xu Ying, Li Peibo, Huang Hairong, Xie Jianping

Abstract excerpt

Mycobacterium tuberculosis (Mtb) infection remains a serious global public health threat due to its inherent and acquired resistance to clinical drugs. Meanwhile, the genomic sequences of many clinical isolates are informative to find novel drugs. Most drug-resistant mutations are clustered in the antibiotics-binding region of the targets, reducing affinity with antibiotics and diminishing the efficacy of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41421076
DOI: 10.1016/j.bioorg.2025.109388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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