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Article

Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis.

PloS one - 1 Jan 2014

Prigozhin Daniil M, Krieger Inna V, Huizar John P, Mavrici Daniela, Waldo Geoffrey S, Hung Li-Wei, Sacchettini James C, Terwilliger Thomas C, Alber Tom

Abstract excerpt

Beta-lactam antibiotics target penicillin-binding proteins including several enzyme classes essential for bacterial cell-wall homeostasis. To better understand the functional and inhibitor-binding specificities of penicillin-binding proteins from the pathogen, Mycobacterium tuberculosis, we carried out structural and phylogenetic analysis of two predicted D,D-carboxypeptidases, Rv2911 and Rv3330. Optimization of...

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Identifiers

PMID: 25551456
DOI: 10.1371/journal.pone.0116249
PMCID: PMC4281109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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