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Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

14 May 2024

Abstract excerpt

Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving selectively directing disease-causing proteins for degradation through proteolytic systems. Our ability to exploit targeted protein degradation (TPD) for antibiotic development remains nascent due to our limited understanding of which bacterial proteins are amenable to a TPD strategy. Here, we use a genetic system to model...

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PMID: 38744895
DOI: 10.1038/s41467-024-48506-8

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