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Mycobacterium smegmatis MfpC is a GEF that regulates mfpA translationally to alter the fluoroquinolone efficacy.

Communications biology - 23 Aug 2024

Huang Yu, Shen Qinglei, Xu Hongxiang, Huang Lingxi, Xiang Shasha, Li Peibo, Fan Lin, Xie Jianping

Abstract excerpt

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a serious threat to global public health. Fluoroquinolones (FQs) are effective against M. tuberculosis; however, resistant strains have limited their efficacy. Mycobacterium fluoroquinolone resistance protein A (MfpA) confers intrinsic resistance to FQs; however, its regulatory mechanisms remain largely unknown. Using M. smegmatis as a model, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39179666
DOI: 10.1038/s42003-024-06737-x
PMCID: PMC11343762

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