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Article

Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis.

Science (New York, N.Y.) - 14 Nov 2008

Pearce Michael J, Mintseris Julian, Ferreyra Jessica, Gygi Steven P, Darwin K Heran

Abstract excerpt

The protein modifier ubiquitin is a signal for proteasome-mediated degradation in eukaryotes. Proteasome-bearing prokaryotes have been thought to degrade proteins via a ubiquitin-independent pathway. We have identified a prokaryotic ubiquitin-like protein, Pup (Rv2111c), which was specifically conjugated to proteasome substrates in the pathogen Mycobacterium tuberculosis. Pupylation occurred on lysines and...

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Identifiers

PMID: 18832610
DOI: 10.1126/science.1163885
PMCID: PMC2698935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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