Article
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.
Neuron - 6 Jan 2016
Zhou Yang, Kaiser Tobias, Monteiro Patrícia, Zhang Xiangyu, Van der Goes Marie S, Wang Dongqing, Barak Boaz, Zeng Menglong, Li Chenchen, Lu Congyi, Wells Michael, Amaya Aldo, Nguyen Shannon, Lewis Michael, Sanjana Neville, Zhou Yongdi, Zhang Mingjie, Zhang Feng, Fu Zhanyan, Feng Guoping
Abstract excerpt
Genetic studies have revealed significant overlaps of risk genes among psychiatric disorders. However, it is not clear how different mutations of the same gene contribute to different disorders. We characterized two lines of mutant mice with Shank3 mutations linked to ASD and schizophrenia. We found both shared and distinct synaptic and behavioral phenotypes. Mice with the ASD-linked InsG3680 mutation manifest...
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