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Article

Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans.

BMC biology - 29 Mar 2018

Hernando-Rodríguez Blanca, Erinjeri Annmary Paul, Rodríguez-Palero María Jesús, Millar Val, González-Hernández Sara, Olmedo María, Schulze Bettina, Baumeister Ralf, Muñoz Manuel J, Askjaer Peter, Artal-Sanz Marta

Abstract excerpt

BACKGROUND: Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabditis elegans to identify genetic interactions, therapeutic drugs or disease modifiers. However, the analysis of essential genes has lagged behind because lethal or sterile mutations pose a...

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Identifiers

PMID: 29598825
DOI: 10.1186/s12915-018-0496-5
PMCID: PMC5875015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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