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Article

Automated screening for mutants affecting dopaminergic-neuron specification in C. elegans.

Nature methods - 1 Oct 2008

Doitsidou Maria, Flames Nuria, Lee Albert C, Boyanov Alexander, Hobert Oliver

Abstract excerpt

We describe an automated method to isolate mutant Caenorhabditis elegans that do not appropriately execute cellular differentiation programs. We used a fluorescence-activated sorting mechanism implemented in the COPAS Biosort machine to isolate mutants with subtle alterations in the cellular specificity of GFP expression. This methodology is considerably more efficient than comparable manual screens and enabled...

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Identifiers

PMID: 18758453
DOI: 10.1038/nmeth.1250
PMCID: PMC2693092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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