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Article

Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development.

Scientific reports - 28 Jun 2017

Offenburger Sarah-Lena, Bensaddek Dalila, Murillo Alejandro Brenes, Lamond Angus I, Gartner Anton

Abstract excerpt

Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in dopaminergic head neuron specification or differentiation, we isolated a new allele of the transcription factor HAM-1 [HSN (Hermaphrodite-Specific Neurons) Abnormal Migration]. Loss of both HAM-1 and its target, the kinase PIG-1...

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Identifiers

PMID: 28659600
DOI: 10.1038/s41598-017-04375-4
PMCID: PMC5489525

Genes

MELK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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