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Article

High-throughput capturing and characterization of mutations in essential genes of Caenorhabditis elegans.

BMC genomics - 12 May 2014

Chu Jeffrey Shih-Chieh, Chua Shu-Yi, Wong Kathy, Davison Ann Marie, Johnsen Robert, Baillie David L, Rose Ann M

Abstract excerpt

BACKGROUND: Essential genes are critical for the development of all organisms and are associated with many human diseases. These genes have been a difficult category to study prior to the availability of balanced lethal strains. Despite the power of targeted mutagenesis, there are limitations in identifying mutations in essential genes. In this paper, we describe the identification of coding regions for essential...

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PMID: 24884423
DOI: 10.1186/1471-2164-15-361
PMCID: PMC4039747

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