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Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score

1 Jan 2021

Abstract excerpt

Abstract Introduction We investigated relationships among genetic determinants of Alzheimer's disease (AD), amyloid/tau/neurodegenaration (ATN) biomarkers, and risk of dementia. Methods We studied cognitively normal individuals with subjective cognitive decline (SCD) from the Amsterdam Dementia Cohort and SCIENCe project. We examined associations between genetic variants and ATN biomarkers, and evaluated their...

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PMID: 34541285
DOI: 10.1002/dad2.12229

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