Article
Prospects for using risk scores in polygenic medicine.
Genome medicine - 13 Nov 2017
Lewis Cathryn M, Vassos Evangelos
Abstract excerpt
Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of complex traits and diseases, including neuropsychiatric disorders. Here, we consider the potential for translation to...
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