Article
No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation.
Clinical epigenetics - 1 Jan 2018
Del Gobbo Giulia F, Price E Magda, Hanna Courtney W, Robinson Wendy P
Abstract excerpt
Background: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in one-carbon metabolism that ensures the availability of methyl groups for methylation reactions. Two single-nucleotide polymorphisms (SNPs) in the MTHFR gene, 677C>T and 1298A>C, result in a thermolabile enzyme with reduced function. These variants, in both the maternal and/or fetal genes, have been associated with pregnancy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.