Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2005

Friso Simonetta, Girelli Domenico, Trabetti Elisabetta, Olivieri Oliviero, Guarini Patrizia, Pignatti Pier Franco, Corrocher Roberto, Choi Sang-Woon

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one-carbon metabolism for DNA synthesis and methylation, both implicated in carcinogenesis. Epidemiologic studies have shown that two functional polymorphisms in MTHFR gene, 677C>T and 1298A>C, are related to increased cancer risk. We aimed to analyze lymphocyte DNA from 198 subjects to evaluate the MTHFR 1298A>C polymorphism and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computers
Share to Epidemiologic Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Homocysteine

Share to Lymphocytes

Share to Methylation

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Source

Identifiers

PMID: 15824167
DOI: 10.1158/1055-9965.EPI-04-0601

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes.PMID 15824167Read ↗

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.Semantic proximity Read ↗

Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele.Semantic proximity Read ↗

Genotype and haplotype distributions of MTHFR677C>T and 1298A>C single nucleotide polymorphisms: a meta-analysis.Semantic proximity Read ↗

Polymorphisms in genes involved in folate metabolism and plasma DNA methylation in colorectal cancer patients.Semantic proximity Read ↗

Role of the MTHFR polymorphisms in cancer risk modification and treatment.Semantic proximity Read ↗

The Frequency of the 677C>T and 1298A>C Polymorphisms in the Methylenetetrahydrofolate Reductase (MTHFR) Gene in the Population.Semantic proximity Read ↗

Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations.Semantic proximity Read ↗

MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer.Semantic proximity Read ↗

Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults.Semantic proximity Read ↗

MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study.Semantic proximity Read ↗

Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with MTHFR Methylation LevelsSemantic proximity Read ↗

Genetic polymorphism of folate and methionine metabolizing enzymes and their susceptibility to malignant lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.