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Article

Hydroxymethylation is uniquely distributed within term placenta, and is associated with gene expression

26 Apr 2016

Abstract excerpt

The conversion of cytosine to 5-methylcystosine (5mC) is an important regulator of gene expression. 5mC may be enzymatically converted to 5-hydroxymethylcytosine (5hmC), with a potentially distinct regulatory function. We sought to investigate these cytosine modifications and their effect on gene expression by parallel processing of genomic DNA using bisulfite and oxidative bisulfite conversion in conjunction...

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PMID: 27118675
DOI: 10.1096/fj.201600310r

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