Article
Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.
PloS one - 1 Jan 2017
Mandaviya Pooja R, Joehanes Roby, Aïssi Dylan, Kühnel Brigitte, Marioni Riccardo E, Truong Vinh, Stolk Lisette, Beekman Marian, Bonder Marc Jan, Franke Lude, Gieger Christian, Huan Tianxiao, Ikram M Arfan, Kunze Sonja, Liang Liming, Lindemans Jan, Liu Chunyu, McRae Allan F, Mendelson Michael M, Müller-Nurasyid Martina, Peters Annette, Slagboom P Eline, Starr John M, Trégouët David-Alexandre, Uitterlinden André G, van Greevenbroek Marleen M J, van Heemst Diana, van Iterson Maarten, Wells Philip S, Yao Chen, Deary Ian J, Gagnon France, Heijmans Bastiaan T, Levy Daniel, Morange Pierre-Emmanuel, Waldenberger Melanie, Heil Sandra G, van Meurs Joyce B J
Abstract excerpt
BACKGROUND: DNA methylation is affected by the activities of the key enzymes and intermediate metabolites of the one-carbon pathway, one of which involves homocysteine. We investigated the effect of the well-known genetic variant associated with mildly elevated homocysteine: MTHFR 677C>T independently and in combination with other homocysteine-associated variants, on genome-wide leukocyte DNA-methylation....
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