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MTHFR Gene Polymorphisms and DNA Methylation in Idiopathic Spontaneous Preterm Birth.

Medicina (Kaunas, Lithuania) - 9 Dec 2024

Dević Pavlić Sanja, Šverko Roberta, Barišić Anita, Mladenić Tea, Vraneković Jadranka, Stanković Aleksandra, Peterlin Ana, Peterlin Borut, Ostojić Saša, Pereza Nina

Abstract excerpt

Background and Objectives: Preterm birth (PTB) is a complex condition with various contributing factors, including genetic and epigenetic influences such as DNA methylation. Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in DNA methylation and the remethylation of homocysteine. This study aimed to investigate the association between maternal MTHFR C677T and A1298C polymorphisms, LINE-1 DNA...

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PMID: 39768908
DOI: 10.3390/medicina60122028

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