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Association between maternal diet, smoking, and the placenta MTHFR 677C/T genotype and global placental DNA methylation.

Placenta - 1 Feb 2024

Diaz-Garcia Hector, Vilchis-Gil Jenny, Castro-Cerritos Karla V, Rivera-Susunaga Luis E, Klünder-Klünder Miguel, Granados-Riveron Javier T, Gómez-López Jaqueline, López-Torres Adolfo, Sánchez-Urbina Rocío

Abstract excerpt

INTRODUCTION: The placenta provides nutrients to the fetus, and it has protective effects against harmful substances. Unhealthy maternal diets and toxic agents might increase free radical (FR) production. Elevated FR levels are associated with a high risk of oxidative stress, which may cause DNA damage. DNA might be oxidized in the placenta, occasionally affecting its methylation profile due to...

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PMID: 38160599
DOI: 10.1016/j.placenta.2023.12.017

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