Article
Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome.
Hypertension in pregnancy - 1 Jan 2000
Zusterzeel P L, Visser W, Blom H J, Peters W H, Heil S G, Steegers E A
Abstract excerpt
OBJECTIVE: To investigate the prevalence of the 677 (C --> T) and 1298 (A --> C) polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene in our preeclamptic population. For a summary estimation of the risk of the 677 (C --> T) polymorphism for preeclampsia, we also performed a meta-analysis on four previously published case-control studies to which our results were added. METHODS: Genotypes were...
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