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Article

Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes.

Scientific reports - 20 Mar 2018

Tawe Leabaneng, Motshoge Thato, Ramatlho Pleasure, Mutukwa Naledi, Muthoga Charles Waithaka, Dongho Ghyslaine Bruna Djeunang, Martinelli Axel, Peloewetse Elias, Russo Gianluca, Quaye Isaac Kweku, Paganotti Giacomo Maria

Abstract excerpt

Identification of inter-individual variability for drug metabolism through cytochrome P450 2B6 (CYP2B6) enzyme is important for understanding the differences in clinical responses to malaria and HIV. This study evaluates the distribution of CYP2B6 alleles, haplotypes and inferred metabolic phenotypes among subjects with different ethnicity in Botswana. A total of 570 subjects were analyzed for CYP2B6...

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Identifiers

PMID: 29559695
DOI: 10.1038/s41598-018-23350-1
PMCID: PMC5861095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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