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African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug Development

21 Feb 2017

Abstract excerpt

Genetic diversity is greater in Africa than in other continental populations. Genetic variability in genes encoding drug metabolizing enzymes may contribute to the high numbers of adverse drug reactions reported in Africa. We reviewed publications (1995-April 2016) reporting frequencies of known cytochrome P450 (CYP) variants in African populations. Using principal components analysis (PCA) we identified CYP...

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PMID: 28237373
DOI: 10.1016/j.ebiom.2017.02.017

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