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Prevalence of Cytochrome P450 2B6 Single Nucleotide Polymorphism in an HIV-Positive Cohort in Jos, Nigeria: Implication for HIV Therapy.

Nigerian journal of clinical practice - 1 Dec 2020

Isaac A O, Wetkos D D, Oche A O, Godwin I, Phyllis K, John A C

Abstract excerpt

BACKGROUND: Africans exhibit great diversity in cytochrome P450 2B6 isoenzyme (CYP2B6), the major enzyme in efavirenz metabolism. AIM: We examined the frequency of two functional single nucleotide polymorphisms (SNPs) of the CYP2B6 pharmacogene in HIV-infected Nigerians on efavirenz-based antiretroviral therapy. The potential implications of the SNPs for HIV therapy were discussed. MATERIALS AND METHODS: A...

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Anti-HIV Agents
Cross-Sectional Studies
Cytochrome P-450 CYP2B6
Genotype
HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 33355828
DOI: 10.4103/njcp.njcp_348_20
PMCID: PMC8576856

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