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The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes: Lessons from Botswana.

Medicine - 29 Apr 2022

Maseng Monkgomotsi J, Tawe Leabaneng, Thami Prisca K, Moyo Sikhulile, Kasvosve Ishmael, Novitsky Vladimir, Essex Max, Russo Gianluca, Gaseitsiwe Simani, Paganotti Giacomo M

Abstract excerpt

ABSTRACT: The two non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP), are currently the core antiretroviral drugs for treatment of HIV in sub-Saharan Africa including Botswana. The drugs are metabolized by Cytochrome P450 2B6 (CYP2B6) liver enzyme. The CYP2B6 gene that encodes for metabolism of these drugs is known to be highly polymorphic. One of the polymorphism in...

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Identifiers

PMID: 35512066
DOI: 10.1097/MD.0000000000029066
PMCID: PMC9276322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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