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Article

Worldwide variation in human drug-metabolism enzyme genes CYP2B6 and UGT2B7: implications for HIV/AIDS treatment.

Pharmacogenomics - 1 Apr 2012

Li Jing, Menard Vincent, Benish Rebekah L, Jurevic Richard J, Guillemette Chantal, Stoneking Mark, Zimmerman Peter A, Mehlotra Rajeev K

Abstract excerpt

AIM: Hepatic enzymes, CYP2B6 and UGT2B7 play a major role in the metabolism of the widely used antiretroviral drugs efavirenz, nevirapine and zidovudine. In the present study, we provide a view of UGT2B7 haplotype structure, and quantify the genetic diversity and differentiation at both CYP2B6 and UGT2B7 genes on a worldwide scale. MATERIALS & METHODS: We genotyped one intronic and three promoter SNPs, and...

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Identifiers

PMID: 22462748
DOI: 10.2217/pgs.11.160
PMCID: PMC3390746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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