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Efficient genome editing in cultured cells and embryos of Debao pig and swamp buffalo using the CRISPR/Cas9 system.

In vitro cellular & developmental biology. Animal - 1 May 2018

Su Xiaoping, Cui Kuiqing, Du Shanshan, Li Hongli, Lu Fenghua, Shi Deshun, Liu Qingyou

Abstract excerpt

Myostatin (MSTN), a protein encoded by growth differentiation factor 8 (GDF8), is primarily expressed in skeletal muscle and negatively regulates the development and regeneration of muscle. Accordingly, myostatin-deficient animals exhibit a double-muscling phenotype. The CRISPR/Cas9 system has proven to be an efficient genome-editing tool and has been applied to gene modification in cells from many model...

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PMID: 29556895
DOI: 10.1007/s11626-018-0236-8

Genes

MSTN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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