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Article

CRISPR/Cas9-mediated knockout of myostatin in Chinese indigenous Erhualian pigs.

Transgenic research - 1 Dec 2017

Wang Kankan, Tang Xiaochun, Xie Zicong, Zou Xiaodong, Li Mengjing, Yuan Hongming, Guo Nannan, Ouyang Hongsheng, Jiao Huping, Pang Daxin

Abstract excerpt

CRISPR/Cas9 has emerged as one of the most popular genome editing tools due to its simple design and high efficiency in multiple species. Myostatin (MSTN) negatively regulates skeletal muscle growth and mutations in myostatin cause double-muscled phenotype in various animals. Here, we generated myostatin mutation in Erhualian pigs using a combination of CRISPR/Cas9 and somatic cell nuclear transfer. The protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28993973
DOI: 10.1007/s11248-017-0044-z

Genes

MSTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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